This paper presents the effect of mechanochemical activation of on the physico-mechanical properties of fine-grained concrete. The optimal time of mechanical activation of cement slurry was defined, at which the maximum increase in the compressive strength of fine-grained concrete was achieved. The quantity of Portland cement activated by its total weight in the composition slurries was experimentally established. The effect of superplasticizer Relamiks T-2 on the properties of fine-grained concrete produced on activated binder for heat cement paste both with and without supplement, was studied. The change of particle size distribution of Portland cement subjected to mechanical activation was shown. The results of experimental studies have shown that mechanochemical activated binder can significantly increase in the early stages of hardening the bending strength (71 %) and compression strength (64 %), and maintain it in project life, which is especially important for monolithic construction. The composition of the particulate activated binder changes significantly, which leads to high physical and mechanical properties of the investigated concrete and its hardening rate.