The problem of design and detailing of monolithic buildings, taking into account the interaction of the masonry filling and frame members is considered. The results of numerical and experimental researches of the masonry filling behavior at the frame twist and deflection of the supporting structures have been presented. It is shown that the filling at the frame twist causes a redistribution of stresses in the columns and floor slabs, that can both have positive and negative effect on its stress-strain state. The necessity of adjusting the standards concerning the limits of floor deflections, against which the masonry walls and partitions abut, has been noted. It is shown that ignoring the joint action of stone filling and skeleton can lead to excessive consumption of materials in the construction of monolithic reinforced concrete buildings, to the additional energy costs and higher prices of construction or, conversely, to an unexpected limit state of infilling and frame members.