The given study is reasoning the relevancy of replacing the conventional elastomer, that is, rubber, with more advanced polyurethane. The paper presents scientific reasoning for the demand to experimentally study the physical and mechanical properties of polyurethane in cases when it is used as plates for vibroisolation of buildings or industrial equipment and is subjected to considerable load. Due to the regulated rate of motor rotation of the testing unit, it is possible to study the course of vibroisolation in a polyurethane bulk, in relation to the forced frequency, vibration amplitude and static deformation. Based on the considerable amount of test measurements of the vibration amplitude with the piezoelectric accelerometers in various stress modes, an empirical statement has been acquired to determine the natural frequency of the polyurethane-unit system for the polyurethane elastomers of varying hardness depending on the degree of relative compression. The present work offers certain recommendations for determining the ultimate static deformation for the polyurethane plates of varying hardness.