The article is dedicated to the funginertness of different construction materials based on acrylates: emulsions Lakroten E-21, Lakroten E-31, Latacryl ZM-1, and Latacryl AF, as well as metacrylate, metacrylate copolymer with metacrylic acid, and n-chlorophenylmetacrylate acrylic glasses. All studied materials, except the Latacryl ZM-1 and copolymer acrylic glasses, demonstrated susceptibility to biodeterioration by microfungi. Multi-compound acrylic compositions appeared to exhibit the emergence, i.e. their funginertness cannot be predicted based on stability of their individual components. Fungal exooxidoreductases (catalase, peroxidase) were defined to contribute into the biodegradation processes in construction materials based on acrylates by micromycetes. The biocides Nuosept 78 and Rosima 243 demonstrated the ability to suppress exo-catalase and exo-peroxidase activity (exo-catalase and exoperoxidase participate in the biodeterioration of the studied materials) in the fungus Aspergillus terreus; thus, they can be recommended for use as means of bioprotection. The non-fungi-resistant acrylic materials were protected from biodeterioration in a targeted and scientifically-grounded way by the introduction of the abovementioned biocidal additives into their compositions. The bioprotection is based on biochemical aspects of biodestructive microfungal activity.