Pipe cooling is one of the effective measures in order to reduce the exothermic heating of massive concrete structures. In this paper, analyzing the influence parameters of the pipe cooling system on the temperature regime and the thermal stress state in mass concrete to be built. The concrete mass was considered as a pillar with dimensions in plan (10×10) m and a final height of 30.0 m. The effect of the following parameters was investigated: the height of the concrete column from the elevation of the foundation is used for the cooling pipe system; the step of cooling pipe system according to the height and width of the concrete block; the temperature of water supplied to the pipe cooling system. Then, numerical studies were carried out by using the Midas civil software package based on the finite element method in order to solve the temperature problem and determine the thermal stress state of the block. From that will be collected the numerical results from pictures of changes in the temperature regime and the thermally stressed state in mass concrete during construction. The influence of each of those factors is considered in order to evaluate the change in temperature regime and thermal stress of the concrete mass. So, the results obtained are of practical importance and can be used to assign parameters of the pipe cooling system.