In the 21st century, wood construction is again widespread. Industrial wood ceased to be perceived as a material for household buildings and low-rise rural houses and began to be used in the construction of large-span, high-rise and unique buildings and structures. The paper analyzes the use of wood for the construction of large-span, high-rise and unique buildings and structures. The results of experimental studies of hollow wooden parts, developed by the authors, impregnated with epoxy compositions, modified by sulfoadducts of nanoclusters of carbon ("Ugleron C") are given. The possibility of external reinforcement of wood with high-strength carbon fiber grids is considered. The technology of additional strengthening of wooden parts by an external membrane from a multifunctional composite water compatible coating "EpoxyPAN" has also been proven. The results of physical and mechanical tests of samples of ultralight hybrid wood-polymer components are presented. The spheres of their application in park construction, wooden bridge construction, construction of wooden high-rise, largespan and unique buildings and structures are analyzed.