Structural seismic design optimization researches reviewing shows that existing economic effect assessment methods take into account only traditional seismic retrofit schemes excluding baseisolation system employment. The purpose of this study is to obtain economic optimization which allows to compare the economic effect E of base-isolated structure among with traditional seismic retrofit schemes. Here the approach is proposed of earthquake caused damage state Drel computation in base-isolated structure considering repair works with due regard to its life-cycle N. The example of damage state Drel evaluation for base-isolated and traditional retrofitted structures is performed considering different seismic intensities. It is shown how the value of damage state proceeds according to the building life-cycle N in each case. The economic effect E for these cases is estimated with the aid of proposed optimization algorithm.