The object of the study is a timber building of frame type, consisting of timber vertical posts, lower and upper binding, a system of connections (horizontal and vertical), elements of overlap and coating (roof). The impact of an earthquake of different intensity and frequency on the seismic resistance of a timber building is considered. Seismic stability was assessed on the basis of experimental and theoretical studies. Experimental methods were performed on laboratory facilities and large-scale models. Taking into account the experimental data obtained, the calculation and theoretical evaluation of the frame building on simple and complex models under the influence of different intensity and frequency composition was performed. It is established that the frequency composition of seismic impact significantly affects the seismic resistance of frame buildings. It is recommended when designing these buildings to assign their dynamic parameters (period of natural oscillations) depending on the forecast of the prevailing period of seismic oscillations of the construction area, which will more effectively solve the layout of the nodal joints of the frame. It is recommended to introduce additional materials and devices having pliability and high dissipative properties into nodal connections.